Ketanserin Tartrate
CAS: 83846-83-7
Name:
Ketanserin Tartrate
Other names:
Ketanserin (+)-tartrate salt; R 41468 (+)-tartrate salt
Ketanserin tartrate is a salt of Ketanserin. Ketanserin is reported to have a high affinity for multiple G protein-coupled receptors, such as serotonin receptors. Ketanserin is a selective SR-2/SR-1C antagonist. It has been used to distinguish between SR-1D and SR-1B subtypes. Additional studies have noted that Ketanserin is able to differentiate between recombinant human forms of these receptors with a higher affinity for SR-1Dα receptors compared to SR-1Dβ receptors. Ketanserin tartrate is an inhibitor of SR-2A and SR-2C.
Interactions
No targets available
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- > 129.0
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
Anti Inflammation
Anti Atherogenic
Anti Depressant
Neuroprotective
Cardioprotective
Antibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
Stress Resistance
Suppression of aging mechanisms
No dataRelation to biomarkers of Aging
Serotonin receptor antagonist, antihypertensive drug, decreases plasma low density lipoprotein
Relation to aging associated genes
No data available
Model organism
ModelCaenorhabditis elegans
SrainN2
Sex—
Age of treatment—
Experimental conditions
S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50Life Extension
- Mean LS (%)
- 13.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0,33%
More info about experiment
Opposite effectNo