Kenpaullone
CAS: 142273-20-9
Name:
Kenpaullone
Other names:
NSC 664704; 9-Bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one; NSC-664704; NSC664704; MLS002702152
Kenpaullone is an ATP-competitive inhibitor of several CDKs (cyclin-dependent kinases) as well as GSK-3β (glycogen synthase kinase 3β). It has been shown to inhibit GSK-3 with an IC50 value of 0.23 μM and CDK1/cyclin B, CDK2/cyclin A, CDK5/p25, and lymphocyte kinase with IC50 values of 0.4, 0.68, 0.85, and 0.47 μM, respectively. Due to the compound’s activity, Kenpaullone is useful in the study of cell cycle regulators. Kenpaullone is an inhibitor of cyclin E, ERK 2 and p35.
Interactions
Description
UniProt ID
Gene: CSNK2A1
Protein: Casein kinase II subunit alpha', Gene: CSNK2A2
Protein: Casein kinase II subunit beta, Gene: CSNK2B
Protein: Cyclin-dependent kinase 1, Gene: CDK1
Protein: Cyclin-dependent kinase 2, Gene: CDK2
Protein: Cyclin-dependent-like kinase 5, Gene: CDK5
Protein: Glycogen synthase kinase-3 alpha, Gene: GSK3A
Protein: Glycogen synthase kinase-3 beta, Gene: GSK3B
Protein: NAD-dependent protein deacetylase sirtuin-2, Gene: SIRT2
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
No dataAntibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
No dataSuppression of aging mechanisms
No dataRelation to biomarkers of Aging
Data not available
Relation to aging associated genes
No data available
Model organism
ModelCaenorhabditis elegans
SrainN2
Sex—
Age of treatment—
Experimental conditions
S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50Life Extension
- Mean LS (%)
- 27.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0,33%
More info about experiment
Opposite effectNo