Kaempferol

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CAS: 520-18-3

Name:

Kaempferol

Other names:

Kempferol; Kaempherol; Populnetin; Rhamnolutein; Robigenin; Trifolitin; Pelargidenolon; Rhamnolutin; Swartziol

Kaempferol is a natural flavonol, a type of flavonoid, found in a variety of plants and plant-derived foods. Kaempferol is a yellow crystalline solid with a melting point of 276–278 °C (529–532 °F). It is slightly soluble in water and highly soluble in hot ethanol, ethers, and DMSO. Kaempferol acts as an antioxidant by reducing oxidative stress. Many studies suggest that consuming kaempferol may reduce the risk of various cancers and kaempferol is currently under consideration as a possible cancer treatment [Wikipedia]

Interactions

Description

UniProt ID

Protein: P2Y purinoceptor 2, Gene: P2RY2
Protein: C-type lectin domain family 14 member A, Gene: CLEC14A
Protein: Gamma-aminobutyric acid receptor subunit alpha-1, Gene: GABRA1
Protein: Gamma-aminobutyric acid receptor subunit alpha-3, Gene: GABRA3
Protein: Gamma-aminobutyric acid receptor subunit alpha-4, Gene: GABRA4
Protein: Gamma-aminobutyric acid receptor subunit alpha-5, Gene: GABRA5
Protein: Gamma-aminobutyric acid receptor subunit alpha-6, Gene: GABRA6
Protein: ATP-binding cassette sub-family G member 2, Gene: ABCG2
Protein: Aryl hydrocarbon receptor, Gene: AHR
Protein: Alcohol dehydrogenase [NADP(+)], Gene: AKR1A1
Protein: Arachidonate 5-lipoxygenase, Gene: ALOX5
Protein: Cyclin-dependent kinase 1, Gene: CDK1
Protein: Cyclin-dependent-like kinase 5, Gene: CDK5
Protein: Cyclin-dependent kinase 6, Gene: CDK6
Protein: Cytochrome P450 1A2, Gene: CYP1A2
Protein: Cytochrome P450 2B6, Gene: CYP2B6
Protein: Cytochrome P450 2C9, Gene: CYP2C9
Protein: Glycogen synthase kinase-3 alpha, Gene: GSK3A
Protein: Glycogen synthase kinase-3 beta, Gene: GSK3B
Protein: Estradiol 17-beta-dehydrogenase 1, Gene: HSD17B1
Protein: 3-keto-steroid reductase, Gene: HSD17B7
Protein: Tyrosine-protein kinase JAK3, Gene: JAK3
Protein: Arylamine N-acetyltransferase 1, Gene: NAT1
Protein: Arylamine N-acetyltransferase 2, Gene: NAT2
Protein: Ribosomal protein S6 kinase alpha-3, Gene: RPS6KA3
Protein: Serine/threonine-protein kinase pim-1, Gene: PIM1
Protein: Serine/threonine-protein kinase PLK1, Gene: PLK1
Protein: Sulfotransferase 1A1, Gene: SULT1A1
Protein: Sulfotransferase, Gene: SULT2A1
Protein: DNA topoisomerase 1, Gene: TOP1
Protein: DNA topoisomerase 2-alpha, Gene: TOP2A
Protein: DNA topoisomerase 2-beta, Gene: TOP2B
Protein: Monocarboxylate transporter 1, Gene: SLC16A1
Protein: Mitogen-activated protein kinase 10, Gene: MAPK10
Protein: Mitogen-activated protein kinase 8, Gene: MAPK8
Protein: Mitogen-activated protein kinase 9, Gene: MAPK9
Protein: Ribosyldihydronicotinamide dehydrogenase [quinone], Gene: NQO2

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Inflammation
Anti Cancer
Anti Amiloid
Anti Atherogenic
Anti Obesity
Neuroprotective
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

Hormetin
+
Stress Resistance

Suppression of aging mechanisms

Anti Oxidant

Relation to biomarkers of Aging

Inhibits cancer cell growth and angiognesis and induces cancer cell apoptosis, but on the other hand, kaempferol appears to preserve normal cell viability, in some cases exerting a protective effect

23497863

Relation to aging associated genes

CDK1TOP1TOP2AGSK3ATOP2BGSK3BMAPK8MAPK9

Experimental conditions

Agar nematode growth medium + E. coli OP50 37oC thermal stress

Life Extension

Mean LS (%)
Median LS (%)
Mortality rate derease (%)
10.0
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

100 mkM

More info about experiment

17551714
Opposite effectNo