Kaempferol

Imageshandler

CAS: 520-18-3

Name:

Kaempferol

Other names:

Kempferol; Kaempherol; Populnetin; Rhamnolutein; Robigenin; Trifolitin; Pelargidenolon; Rhamnolutin; Swartziol

Kaempferol is a natural flavonol, a type of flavonoid, found in a variety of plants and plant-derived foods. Kaempferol is a yellow crystalline solid with a melting point of 276–278 °C (529–532 °F). It is slightly soluble in water and highly soluble in hot ethanol, ethers, and DMSO. Kaempferol acts as an antioxidant by reducing oxidative stress. Many studies suggest that consuming kaempferol may reduce the risk of various cancers and kaempferol is currently under consideration as a possible cancer treatment [Wikipedia]

ChemSpider

DrugBank

ChEMBL

ChEBI

PubChem

Drug Status

Not a drug

Clinical trials

0 Studies

Interactions

Description

UniProt ID

Protein: P2Y purinoceptor 2, Gene: P2RY2
P41231
Protein: C-type lectin domain family 14 member A, Gene: CLEC14A
Q86T13
Protein: Gamma-aminobutyric acid receptor subunit alpha-1, Gene: GABRA1
P14867
Protein: Gamma-aminobutyric acid receptor subunit alpha-3, Gene: GABRA3
P34903
Protein: Gamma-aminobutyric acid receptor subunit alpha-4, Gene: GABRA4
P48169
Protein: Gamma-aminobutyric acid receptor subunit alpha-5, Gene: GABRA5
P31644
Protein: Gamma-aminobutyric acid receptor subunit alpha-6, Gene: GABRA6
Q16445
Protein: ATP-binding cassette sub-family G member 2, Gene: ABCG2
Q9UNQ0
Protein: Aryl hydrocarbon receptor, Gene: AHR
P35869
Protein: Alcohol dehydrogenase [NADP(+)], Gene: AKR1A1
P14550
Protein: Arachidonate 5-lipoxygenase, Gene: ALOX5
P09917
Protein: Cyclin-dependent kinase 1, Gene: CDK1
P06493
Protein: Cyclin-dependent-like kinase 5, Gene: CDK5
Q00535
Protein: Cyclin-dependent kinase 6, Gene: CDK6
Q00534
Protein: Cytochrome P450 1A2, Gene: CYP1A2
P05177
Protein: Cytochrome P450 2B6, Gene: CYP2B6
P20813
Protein: Cytochrome P450 2C9, Gene: CYP2C9
P11712
Protein: Glycogen synthase kinase-3 alpha, Gene: GSK3A
P49840
Protein: Glycogen synthase kinase-3 beta, Gene: GSK3B
P49841
Protein: Estradiol 17-beta-dehydrogenase 1, Gene: HSD17B1
P14061
Protein: 3-keto-steroid reductase, Gene: HSD17B7
P56937
Protein: Tyrosine-protein kinase JAK3, Gene: JAK3
P52333
Protein: Arylamine N-acetyltransferase 1, Gene: NAT1
P18440
Protein: Arylamine N-acetyltransferase 2, Gene: NAT2
P11245
Protein: Ribosomal protein S6 kinase alpha-3, Gene: RPS6KA3
P51812
Protein: Serine/threonine-protein kinase pim-1, Gene: PIM1
P11309
Protein: Serine/threonine-protein kinase PLK1, Gene: PLK1
P53350
Protein: Sulfotransferase 1A1, Gene: SULT1A1
P50225
Protein: Sulfotransferase, Gene: SULT2A1
A8K015
Protein: DNA topoisomerase 1, Gene: TOP1
P11387
Protein: DNA topoisomerase 2-alpha, Gene: TOP2A
P11388
Protein: DNA topoisomerase 2-beta, Gene: TOP2B
Q02880
Protein: Monocarboxylate transporter 1, Gene: SLC16A1
P53985
Protein: Mitogen-activated protein kinase 10, Gene: MAPK10
P53779
Protein: Mitogen-activated protein kinase 8, Gene: MAPK8
P45983
Protein: Mitogen-activated protein kinase 9, Gene: MAPK9
P45984
Protein: Ribosyldihydronicotinamide dehydrogenase [quinone], Gene: NQO2
P16083

Related pathways

No information yet

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Inflammation
24502634
Anti Cancer
24700700
Anti Amiloid
20139605
Anti Atherogenic
23895132
Anti Obesity
22108137
Neuroprotective
21804220
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

Hormetin
+
Stress Resistance
22155320

Suppression of aging mechanisms

Anti Oxidant
23634640

Relation to biomarkers of Aging

Inhibits cancer cell growth and angiognesis and induces cancer cell apoptosis, but on the other hand, kaempferol appears to preserve normal cell viability, in some cases exerting a protective effect

23497863

Relation to aging associated genes

CDK1TOP1TOP2AGSK3ATOP2BGSK3BMAPK8MAPK9

Model organism

ModelCaenorhabditis elegans
SrainN2
Sex—
Age of treatment—

Experimental conditions

Agar nematode growth medium + E. coli OP50 37oC thermal stress

Life Extension

Mean LS (%)
—
Median LS (%)
—
Mortality rate derease (%)
10.0
Max LS (%)
—
Cell CLS
—
Cell RLS
—

Concentration wth maximum effect

100 mkM

More info about experiment

17551714
Opposite effectNo