Ha-1004

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CAS: 91742-10-8

Name:

Ha-1004

Other names:

N-(2-guanidinoethyl)-5-isoquinolinesulfonamide; Dihydrochloride; N-(2-Guanidinoethyl)-5-isoquinolinesulfonamide, 2HCl; AGN-PC-015JSH

HA-1004 has been shown to act as a potent inhibitor of PKA (cyclic AMP-dependent protein kinase), cGKI (cyclic GMP-dependent protein kinase), PKC, and MYLK at the intracellular or submembranal level. It has also been shown to act as calcium channel protein inhibitor and vasodilator, relaxing vascular smooth muscle.

Interactions

Description

UniProt ID

Protein: A-kinase anchor protein 4, Gene: AKAP4
Protein: Calcium/calmodulin-dependent protein kinase type II subunit alpha, Gene: CAMK2A
Protein: Calcium/calmodulin-dependent protein kinase type II subunit beta, Gene: CAMK2B
Gene: CAMK2D
Gene: CAMK2G
Protein: Protein kinase C alpha type, Gene: PRKCA
Protein: Protein kinase C beta type, Gene: PRKCB
Protein: Protein kinase C delta type, Gene: PRKCD
Protein: Protein kinase C epsilon type, Gene: PRKCE
Protein: Protein kinase C gamma type, Gene: PRKCG
Protein: Protein kinase C eta type, Gene: PRKCH
Protein: Protein kinase C iota type, Gene: PRKCI
Protein: Protein kinase C theta type, Gene: PRKCQ
Protein: Protein kinase C zeta type, Gene: PRKCZ
Protein: Serine/threonine-protein kinase D1, Gene: PRKD1
Gene: PRKD2
Protein: Serine/threonine-protein kinase D3, Gene: PRKD3

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Cardioprotective
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

No data

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Data not available

Relation to aging associated genes

PRKCAPRKCD

Experimental conditions

Not available

Life Extension

Mean LS (%)
18.0
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

1-10 mkM

More info about experiment

22363408
Opposite effectNo