Ha-1004
CAS: 91742-10-8
Name:
Ha-1004
Other names:
N-(2-guanidinoethyl)-5-isoquinolinesulfonamide; Dihydrochloride; N-(2-Guanidinoethyl)-5-isoquinolinesulfonamide, 2HCl; AGN-PC-015JSH
HA-1004 has been shown to act as a potent inhibitor of PKA (cyclic AMP-dependent protein kinase), cGKI (cyclic GMP-dependent protein kinase), PKC, and MYLK at the intracellular or submembranal level. It has also been shown to act as calcium channel protein inhibitor and vasodilator, relaxing vascular smooth muscle.
Interactions
Description
UniProt ID
Protein: A-kinase anchor protein 4, Gene: AKAP4
Protein: Calcium/calmodulin-dependent protein kinase type II subunit alpha, Gene: CAMK2A
Protein: Calcium/calmodulin-dependent protein kinase type II subunit beta, Gene: CAMK2B
Gene: CAMK2D
Gene: CAMK2G
Protein: Protein kinase C alpha type, Gene: PRKCA
Protein: Protein kinase C beta type, Gene: PRKCB
Protein: Protein kinase C delta type, Gene: PRKCD
Protein: Protein kinase C epsilon type, Gene: PRKCE
Protein: Protein kinase C gamma type, Gene: PRKCG
Protein: Protein kinase C eta type, Gene: PRKCH
Protein: Protein kinase C iota type, Gene: PRKCI
Protein: Protein kinase C theta type, Gene: PRKCQ
Protein: Protein kinase C zeta type, Gene: PRKCZ
Protein: Serine/threonine-protein kinase D1, Gene: PRKD1
Gene: PRKD2
Protein: Serine/threonine-protein kinase D3, Gene: PRKD3
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Model organism
ModelDrosophila melanogaster
SrainOregon-R-C
Sex—
Age of treatment—
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- 18.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
1-10 mkM
More info about experiment
Opposite effectNo