Guanfacine Hydrochloride
CAS: 29110-48-3
Name:
Guanfacine Hydrochloride
Other names:
Tenex; Estulic; Intuniv; Connexyn; GUANFACINE HCL; Prestwick_740; Tenex (TN); C9H9Cl2N3O.HCl; AC1L2G3E
Guanfacine hydrochloride, a centrally acting anti-hypertensive agent, has been reported to be a specific α2A-AR adrenoceptor agonist. Activation of these α2A-AR adrenoreceptors has been shown to cause a decrease in blood pressure in vitro. Additional studies suggest that Guanfacine hydrochloride plays a role in solute/sodium osmoregulation and excretion.
Interactions
Description
UniProt ID
Protein: Alpha-2A adrenergic receptor, Gene: ADRA2A
Protein: Multidrug and toxin extrusion protein 1, Gene: SLC47A1
Toxicity
- oral LD50 [mouse] mg/kg
- > 15300.0
- oral LD50 [rat] mg/kg
- > 142.0
- oral LD50 [rabbit] mg/kg
- Unavailable
Antibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
No dataSuppression of aging mechanisms
No dataRelation to aging associated genes
No data available
Model organism
ModelCaenorhabditis elegans
SrainN2
Sex—
Age of treatment—
Experimental conditions
S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50Life Extension
- Mean LS (%)
- 15.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0,33%
More info about experiment
Opposite effectNo