Guanabenz Acetate
CAS: 23256-50-0
Name:
Guanabenz Acetate
Other names:
Wytensin; Guanabenz acetate; Guanabenz monoacetate; Acetate; Guanabenz; Monoacetate; Wy 8678; Wy-8678
Guanabenz acetate is an α2A-AR adrenergic agonist and IGRS (imidazoline I2 binding site) selective ligand. Guanabenz acetate is an activator of alpha2B-AR (α2b-adrenergic receptor) and alpha2C-AR (α2c-adrenergic receptor).
Interactions
Description
UniProt ID
Protein: Alpha-2A adrenergic receptor, Gene: ADRA2A
Protein: Alpha-2B adrenergic receptor, Gene: ADRA2B
Protein: 5-hydroxytryptamine receptor 1A, Gene: HTR1A
Protein: Amine oxidase [flavin-containing] A, Gene: MAOA
Protein: Amine oxidase [flavin-containing] B, Gene: MAOB
Protein: Nanos homolog 1, Gene: NANOS1
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- > 238.0
- oral LD50 [rabbit] mg/kg
- Unavailable
Antibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
Stress Resistance
Suppression of aging mechanisms
Anti Oxidant
+
Relation to aging associated genes
No data available
Model organism
ModelCaenorhabditis elegans
SrainN2
Sex—
Age of treatment—
Experimental conditions
S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50Life Extension
- Mean LS (%)
- 12.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0,33%
More info about experiment
Opposite effectNo