Glutathione

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CAS: 70-18-8

Name:

Glutathione

Other names:

Reduced glutathione; Isethion; Tathion; Copren; L-Glutathione; Deltathione; Glutathion; Glutinal; Tathione; Glutide

Glutathione (GSH) is an important antioxidant in plants, animals, fungi, and some bacteria and archaea, preventing damage to important cellular components caused by reactive oxygen species such as free radicals, peroxides, lipid peroxides and heavy metals.[2] It is a tripeptide with a gamma peptide linkage between the carboxyl group of the glutamate side-chain and the amine group of cysteine (which is attached by normal peptide linkage to a glycine). [Wikipedia]

Interactions

Description

UniProt ID

Protein: Extracellular calcium-sensing receptor, Gene: CASR
Protein: Ganglioside-induced differentiation-associated protein 1-like 1, Gene: GDAP1L1
Protein: Protein disulfide-isomerase A3, Gene: PDIA3
Protein: Putative protein PTGES3L, Gene: PTGES3L
Protein: Actin, cytoplasmic 1, Gene: ACTB
Protein: Tyrosine-protein phosphatase non-receptor type 13, Gene: PTPN13
Protein: Tyrosine-protein phosphatase non-receptor type, Gene: PTPN1
Protein: Apoptosis regulator BAX, Gene: BAX
Protein: Aldose reductase, Gene: AKR1B1
Protein: Chloride intracellular channel protein, Gene: CLIC1
Protein: Sphingomyelin phosphodiesterase 2, Gene: SMPD2
Protein: Paired box protein Pax-8, Gene: PAX8
Protein: Carbonic anhydrase 3, Gene: CA3
Protein: Thioredoxin, mitochondrial, Gene: TXN2

Toxicity

oral LD50 [mouse] mg/kg
> 5000.0
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

No data
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

Calorie Restriction Mimetics

Suppression of aging mechanisms

Anti Oxidant

Relation to biomarkers of Aging

Preventing the oxidation of lens proteins from various oxidants

8268853

Relation to aging associated genes

PTPN11BAX

Experimental conditions

C. elegans was maintained and propagated on peptone-free modified nematode growth medium (NGM) + E. coli OP50

Life Extension

Mean LS (%)
73.33
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

640–768 pg per worm per day

More info about experiment

19580823
Opposite effectNo