Glutathione
CAS: 70-18-8
Name:
Glutathione
Other names:
Reduced glutathione; Isethion; Tathion; Copren; L-Glutathione; Deltathione; Glutathion; Glutinal; Tathione; Glutide
Glutathione (GSH) is an important antioxidant in plants, animals, fungi, and some bacteria and archaea, preventing damage to important cellular components caused by reactive oxygen species such as free radicals, peroxides, lipid peroxides and heavy metals.[2] It is a tripeptide with a gamma peptide linkage between the carboxyl group of the glutamate side-chain and the amine group of cysteine (which is attached by normal peptide linkage to a glycine). [Wikipedia]
Interactions
Description
UniProt ID
Protein: Extracellular calcium-sensing receptor, Gene: CASR
Protein: Ganglioside-induced differentiation-associated protein 1-like 1, Gene: GDAP1L1
Protein: Protein disulfide-isomerase A3, Gene: PDIA3
Protein: Putative protein PTGES3L, Gene: PTGES3L
Protein: Actin, cytoplasmic 1, Gene: ACTB
Protein: Tyrosine-protein phosphatase non-receptor type 13, Gene: PTPN13
Protein: Tyrosine-protein phosphatase non-receptor type, Gene: PTPN1
Protein: Apoptosis regulator BAX, Gene: BAX
Protein: Aldose reductase, Gene: AKR1B1
Protein: Chloride intracellular channel protein, Gene: CLIC1
Protein: Sphingomyelin phosphodiesterase 2, Gene: SMPD2
Protein: Paired box protein Pax-8, Gene: PAX8
Protein: Carbonic anhydrase 3, Gene: CA3
Protein: Thioredoxin, mitochondrial, Gene: TXN2
Toxicity
- oral LD50 [mouse] mg/kg
- > 5000.0
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
No dataAntibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
Calorie Restriction Mimetics
Suppression of aging mechanisms
Anti Oxidant
Relation to biomarkers of Aging
Preventing the oxidation of lens proteins from various oxidants
Model organism
ModelCaenorhabditis elegans
SrainN2
Sex—
Age of treatment—
Experimental conditions
C. elegans was maintained and propagated on peptone-free modified nematode growth medium (NGM) + E. coli OP50Life Extension
- Mean LS (%)
- 73.33
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
640–768 pg per worm per day
More info about experiment
Opposite effectNo