Ggti-298
CAS: 180977-44-0
Name:
Ggti-298
Other names:
Ggti 298; C102521
GGTI 298 has been shown to be a CAAZ peptidomimetic GGTase I (geranylgeranyltransferase I) inhibitor. This compound has been shown to cause G0-G1 cell cycle block and apoptosis in A549 cells.
Interactions
Description
UniProt ID
Protein: Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, Gene: FNTA
Protein: Geranylgeranyl transferase type-1 subunit beta, Gene: PGGT1B
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Model organism
ModelDrosophila Melanogaster
SrainOregon-R-C
Sex—
Age of treatment—
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- —
- Median LS (%)
- 22.0
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
300 mkM
More info about experiment
Opposite effectNo