Ggti-298

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CAS: 180977-44-0

Name:

Ggti-298

Other names:

Ggti 298; C102521

GGTI 298 has been shown to be a CAAZ peptidomimetic GGTase I (geranylgeranyltransferase I) inhibitor. This compound has been shown to cause G0-G1 cell cycle block and apoptosis in A549 cells.

Interactions

Description

UniProt ID

Protein: Geranylgeranyl transferase type-1 subunit beta, Gene: PGGT1B
Protein: Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, Gene: FNTA

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Cancer
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

No data

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Increased osteoblastogenesis

21077849

Relation to aging associated genes

No data available

Experimental conditions

Not available

Life Extension

Mean LS (%)
Median LS (%)
22.0
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

300 mkM

More info about experiment

22737247
Opposite effectNo