Fisetin
CAS: 528-48-3
Name:
Fisetin
Other names:
5-Desoxyquercetin; Fisetholz; Superfustel; Cotinin; Fietin; Fustel; Fustet; Viset
Fisetin is a flavone which acts as an inhibitor of Akt, Cdk6, mTOR and PI 3-kinase and an activator of ERK. It has been shown to inhibit melanoma cell growth via its mTOR binding activity.
Interactions
Description
UniProt ID
Protein: Alcohol dehydrogenase [NADP(+)], Gene: AKR1A1
Protein: Cyclin-dependent kinase 1, Gene: CDK1
Protein: Cyclin-dependent-like kinase 5, Gene: CDK5
Protein: Cyclin-dependent kinase 6, Gene: CDK6
Protein: Catechol O-methyltransferase, Gene: COMT
Protein: Cytochrome P450 1A2, Gene: CYP1A2
Protein: Cytochrome P450 2C9, Gene: CYP2C9
Gene: CYP3A4
Protein: Glycogen synthase kinase-3 alpha, Gene: GSK3A
Protein: Glycogen synthase kinase-3 beta, Gene: GSK3B
Protein: Estradiol 17-beta-dehydrogenase 1, Gene: HSD17B1
Protein: Serine/threonine-protein kinase pim-1, Gene: PIM1
Protein: Serine/threonine-protein kinase PLK1, Gene: PLK1
Protein: Sulfotransferase 1A1, Gene: SULT1A1
Protein: DNA topoisomerase 2-alpha, Gene: TOP2A
Protein: DNA topoisomerase 2-beta, Gene: TOP2B
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
Anti Inflammation
Anti Cancer
Anti Atherogenic
Anti Obesity
Anti Diabetic
Antibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
Calorie Restriction Mimetics
+
Stress Resistance
Suppression of aging mechanisms
Anti Oxidant
Relation to biomarkers of Aging
Inhibits high-glucose-induced vascular inflammation in vitro and in vivo
Model organism
ModelSaccharomyces cerevisiae
SrainPSY316AT MATa
Sex—
Age of treatment—
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- —
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- 55.0
Concentration wth maximum effect
More info about experiment
Opposite effectNo
Model organism
ModelCaenorhabiditis elegans
SrainN2
Sex—
Age of treatment—
Experimental conditions
Agar nematode growth medium + E. coli OP50 37oC thermal stressLife Extension
- Mean LS (%)
- 5.6
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
100 mkM
More info about experiment
Opposite effectNo
Model organism
ModelDrosophila melanogaster
SrainCanton-S
Sex—
Age of treatment—
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- 23.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
100 mkM
More info about experiment
Opposite effectNo