Fisetin

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CAS: 528-48-3

Name:

Fisetin

Other names:

5-Desoxyquercetin; Fisetholz; Superfustel; Cotinin; Fietin; Fustel; Fustet; Viset

Fisetin is a flavone which acts as an inhibitor of Akt, Cdk6, mTOR and PI 3-kinase and an activator of ERK. It has been shown to inhibit melanoma cell growth via its mTOR binding activity.

Interactions

Description

UniProt ID

Protein: Alcohol dehydrogenase [NADP(+)], Gene: AKR1A1
Protein: Cyclin-dependent kinase 1, Gene: CDK1
Protein: Cyclin-dependent-like kinase 5, Gene: CDK5
Protein: Cyclin-dependent kinase 6, Gene: CDK6
Protein: Catechol O-methyltransferase, Gene: COMT
Protein: Cytochrome P450 1A2, Gene: CYP1A2
Protein: Cytochrome P450 2C9, Gene: CYP2C9
Gene: CYP3A4
Protein: Glycogen synthase kinase-3 alpha, Gene: GSK3A
Protein: Glycogen synthase kinase-3 beta, Gene: GSK3B
Protein: Estradiol 17-beta-dehydrogenase 1, Gene: HSD17B1
Protein: Serine/threonine-protein kinase pim-1, Gene: PIM1
Protein: Serine/threonine-protein kinase PLK1, Gene: PLK1
Protein: Sulfotransferase 1A1, Gene: SULT1A1
Protein: DNA topoisomerase 2-alpha, Gene: TOP2A
Protein: DNA topoisomerase 2-beta, Gene: TOP2B

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Inflammation
Anti Cancer
Anti Atherogenic
Anti Obesity
Anti Diabetic
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

Calorie Restriction Mimetics
+
Stress Resistance

Suppression of aging mechanisms

Anti Oxidant

Relation to biomarkers of Aging

Inhibits high-glucose-induced vascular inflammation in vitro and in vivo

24923846 25263652

Relation to aging associated genes

CDK1TOP2AGSK3ATOP2BGSK3B

Experimental conditions

Not available

Life Extension

Mean LS (%)
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS
55.0

Concentration wth maximum effect

More info about experiment

12939617
Opposite effectNo

Experimental conditions

Agar nematode growth medium + E. coli OP50 37oC thermal stress

Life Extension

Mean LS (%)
5.6
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

100 mkM

More info about experiment

17551714
Opposite effectNo

Experimental conditions

Not available

Life Extension

Mean LS (%)
23.0
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

100 mkM

More info about experiment

15254550
Opposite effectNo