Fenofibrate
CAS: 49562-28-9
Name:
Fenofibrate
Other names:
Lipanthyl; Antara; Tricor; Procetofen; Lipantil; Triglide; Lipidil; Secalip; Proctofene
An antilipemic agent which reduces both cholesterol and triglycerides in the blood. [PubChem]
Interactions
Description
UniProt ID
Protein: Cationic amino acid transporter 2, Gene: SLC7A2
Protein: Enoyl-CoA hydratase, mitochondrial, Gene: ECHS1
Protein: Aldo-keto reductase family 1 member B10, Gene: AKR1B10
Protein: Aldose reductase, Gene: AKR1B1
Protein: Liver carboxylesterase 1, Gene: CES1
Protein: Carboxylic ester hydrolase, Gene: CES2
Protein: Corticosteroid 11-beta-dehydrogenase isozyme 1, Gene: HSD11B1
Gene: SLCO1B1
Toxicity
- oral LD50 [mouse] mg/kg
- > 1600.0
- oral LD50 [rat] mg/kg
- > 0.0
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
Anti Inflammation
Anti Cancer
Anti Amiloid
Anti Atherogenic
Anti Obesity
Anti Diabetic
Neuroprotective
Cardioprotective
Antibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
No dataSuppression of aging mechanisms
No dataRelation to biomarkers of Aging
Selective peroxisome proliferator-activated receptors alpha (PPAR-a) activator; Improves Vascular Endothelial Function
Relation to aging associated genes
No data available
Model organism
ModelCaenorhabiditis elegans
SrainN2
Sex—
Age of treatment—
Experimental conditions
Agar nematode growth medium + E. coli OP50Life Extension
- Mean LS (%)
- 18.52
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- 16.7
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
10 mkM
More info about experiment
Opposite effectNo