Fenofibrate

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CAS: 49562-28-9

Name:

Fenofibrate

Other names:

Lipanthyl; Antara; Tricor; Procetofen; Lipantil; Triglide; Lipidil; Secalip; Proctofene

An antilipemic agent which reduces both cholesterol and triglycerides in the blood. [PubChem]

Interactions

Description

UniProt ID

Protein: Carboxylic ester hydrolase, Gene: CES2
Protein: Cationic amino acid transporter 2, Gene: SLC7A2
Protein: Corticosteroid 11-beta-dehydrogenase isozyme 1, Gene: HSD11B1
Protein: Liver carboxylesterase 1, Gene: CES1
Protein: Aldose reductase, Gene: AKR1B1
Protein: Aldo-keto reductase family 1 member B10, Gene: AKR1B10
Protein: Enoyl-CoA hydratase, mitochondrial, Gene: ECHS1
Gene: SLCO1B1

Toxicity

oral LD50 [mouse] mg/kg
> 1600.0
oral LD50 [rat] mg/kg
> 0.0
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Inflammation
Anti Cancer
Anti Amiloid
Anti Atherogenic
Anti Obesity
Anti Diabetic
Neuroprotective
Cardioprotective
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

No data

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Selective peroxisome proliferator-activated receptors alpha (PPAR-a) activator; Improves Vascular Endothelial Function

[http://cdn.intechopen.com/pdfs-wm/27510.pdf] 23108655

Relation to aging associated genes

No data available

Experimental conditions

Agar nematode growth medium + E. coli OP50

Life Extension

Mean LS (%)
18.52
Median LS (%)
Mortality rate derease (%)
Max LS (%)
16.7
Cell CLS
Cell RLS

Concentration wth maximum effect

10 mkM

More info about experiment

23603800
Opposite effectNo