Euk-134
CAS: 81065-76-1
Name:
Euk-134
Other names:
(SP-5-13)-Chloro[[2,2′-[1,2-ethanediylbis[(nitrilo-?N)methylidyne]]bis[6-methoxyphenolato-KO]](2-)]-manganese; EUK 134; SALEN-MN; SALEN-MN/EUK-134; Manganese (salen-3,3'-diMethoxy) chloride; ETHYLBISIMINOMETHYLGUAIACOL MANGANESE CHLORIDE; CHLORO[[2,2'-[1,2-ETHANEDIYLBIS[(NITRILO-KAPPAN)METHYLIDYNE]]BIS[6-METHOXYPHENOLATO-KAPPAO]]]-MANGANESE; Chloro[[2,2'-[1,2-ethanediylbis(nitrilomethylidyne)]bis[6-methoxyphenolato]](2-)-N2,N2',O1,O1']manganese
EUK 134 is a synthetic manganese-porphyrin complex which has been documented to act as a scavenger for oxidative species such as hydrogen peroxide, peroxynitrite and superoxide. This compound is a salen-manganese complex that has been modified to increase its catalase activity while retaining SOD activity.
Interactions
No targets available
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
No
No
No
Longevity mechanisms activation
No dataSuppression of aging mechanisms
Relation to aging associated genes
No data available
Model organism
Experimental conditions
S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50Life Extension
- Mean LS (%)
- 38.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- 46.0
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0,5 mM