Enalapril
CAS: 75847-73-3
Name:
Enalapril
Other names:
Vasotec; Enalaprilum; CHEBI:4784; Acetensil; Amprace; Feliberal; NCGC00021569-04; DSSTox_CID_2982; DSSTox_RID_76817
Enalapril is a prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to enalaprilat following oral administration. Enalaprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Enalapril may be used to treat essential or renovascular hypertension and symptomatic congestive heart failure.
Interactions
No targets available
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
Anti Inflammation
Anti Cancer
Anti Obesity
Cardioprotective
Antibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
Calorie Restriction Mimetics
Suppression of aging mechanisms
Anti Oxidant
Relation to aging associated genes
No data available
Model organism
ModelRat
SrainWistar
Sex—
Age of treatment—
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- —
- Median LS (%)
- —
- Mortality rate derease (%)
- 40.0
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
10 mg/kg/day
More info about experiment
Opposite effectNo