Ellagic Acid

Imageshandler

CAS: 476-66-4

Name:

Ellagic Acid

Other names:

Benzoaric acid; Lagistase; Eleagic acid; Alizarine Yellow; Elagostasine; Ellagic acid dihydrate; Llagic acid

Ellagic acid is present in several fruits such as cranberries, strawberries, raspberries, and pomegranates. In pomegranates, there are several therapeutic compounds but ellagic acid is the most active and abundant. Ellagic acid is also present in vegetables. Ellagic acid is an investigational drug studied for treatment of Follicular Lymphoma (phase 2 trial), protection from brain injury of intrauterine growth restricted babies (phase 1 and 2 trial), improvement of cardiovascular function in adolescents who are obese (phase 2 trial), and topical treatment of solar lentigines. Ellagic acid’s therapeutic action mostly involves antioxidant and anti-proliferative effects.

Interactions

Description

UniProt ID

Protein: Elastin, Gene: ELN
Protein: Coagulation factor XII, Gene: F12
Protein: Beta-secretase 1, Gene: BACE1
Protein: Solute carrier family 22 member 11, Gene: SLC22A11
Protein: Solute carrier family 22 member 6, Gene: SLC22A6
Protein: Vascular endothelial growth factor receptor 2, Gene: KDR
Protein: Aldose reductase, Gene: AKR1B1
Protein: Aldo-keto reductase family 1 member B10, Gene: AKR1B10
Protein: Alcohol dehydrogenase [NADP(+)], Gene: AKR1A1
Protein: Proto-oncogene tyrosine-protein kinase Src, Gene: SRC
Gene: CSNK2A1
Protein: Casein kinase II subunit alpha', Gene: CSNK2A2
Gene: ERG1
Protein: Inositol polyphosphate multikinase, Gene: IPMK
Protein: Inositol-trisphosphate 3-kinase A, Gene: ITPKA
Protein: Inositol-trisphosphate 3-kinase B, Gene: ITPKB
Protein: Inositol-trisphosphate 3-kinase C, Gene: ITPKC
Protein: Protein kinase C alpha type, Gene: PRKCA
Protein: Protein kinase C beta type, Gene: PRKCB
Protein: Protein kinase C delta type, Gene: PRKCD
Protein: Protein kinase C epsilon type, Gene: PRKCE
Protein: Protein kinase C gamma type, Gene: PRKCG
Protein: Protein kinase C eta type, Gene: PRKCH
Protein: Protein kinase C iota type, Gene: PRKCI
Protein: Protein kinase C theta type, Gene: PRKCQ
Protein: Protein kinase C zeta type, Gene: PRKCZ
Protein: Serine/threonine-protein kinase D1, Gene: PRKD1
Gene: PRKD2
Protein: Serine/threonine-protein kinase D3, Gene: PRKD3
Protein: DNA topoisomerase 1, Gene: TOP1
Protein: DNA topoisomerase 2-alpha, Gene: TOP2A
Protein: DNA topoisomerase 2-beta, Gene: TOP2B
Protein: DNA topoisomerase 2-alpha, Gene: TOP2A
Protein: DNA topoisomerase 2-beta, Gene: TOP2B
Protein: 5'-AMP-activated protein kinase catalytic subunit alpha-2, Gene: PRKAA2

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
> 20000.0
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Inflammation
Anti Cancer
Anti Amiloid
Anti Atherogenic
Anti Obesity
Anti Diabetic
Anti Depressant
Neuroprotective
Cardioprotective
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

No data

Suppression of aging mechanisms

Anti Age
Metal Ion Chelating
Anti Oxidant

Relation to biomarkers of Aging

Alleviates skin wrinkle and inflammation induced by UV-B irradiation

20113347

Relation to aging associated genes

SHC1PRKCAPRKCDTOP1TOP2ATOP2ATOP2BTOP2BELNRET

Experimental conditions

Agar nematode growth medium + E. coli OP50

Life Extension

Mean LS (%)
10.0
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

50 mkM

More info about experiment

21805983
Opposite effectNo