Doxazosin Mesylate

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CAS: 77883-43-3

Name:

Doxazosin Mesylate

Other names:

Doxazosin mesylate; Carduran; Cardular; Cardura; Cardura XL; Doxazomerck; Cardenalin; Dedralen; Progandol; Tensiobas

Doxazosin Mesylate is an α-blocker drug related to prazosin, specifically acting as an AR (α-1-adrenoceptor) antagonist. Doxazosin Mesylate inhibits the binding of norepinephrine to the α-1 receptors on the membrane of vascular smooth muscle cells. The primary effect of this inhibition is relaxed vascular smooth muscle tone (vasodilation), which decreases peripheral vascular resistance, leading to decreased blood pressure.

Interactions

No targets available

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
> 0.0
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Cardioprotective
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

No data

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Data not available

Relation to aging associated genes

No data available

Experimental conditions

S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50

Life Extension

Mean LS (%)
15.0
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

0,33%

More info about experiment

24134630
Opposite effectNo