Dimethyl Sulfoxide
CAS: 67-68-5
Name:
Dimethyl Sulfoxide
Other names:
DMSO; Methyl sulfoxide; Dimethyl sulphoxide; Methylsulfinylmethane; Demasorb, Dimexide; Domoso; Demsodrox; Dromisol
A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during cryopreservation. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation. [PubChem]
Interactions
Description
UniProt ID
Protein: UDP-glucuronosyltransferase 1-1, Gene: UGT1A1
Protein: UDP-glucuronosyltransferase 1-10, Gene: UGT1A10
Protein: Occludin, Gene: OCLN
Protein: Protein kinase C alpha type, Gene: PRKCA
Protein: Protein kinase C beta type, Gene: PRKCB
Protein: Protein kinase C delta type, Gene: PRKCD
Protein: Protein kinase C epsilon type, Gene: PRKCE
Protein: Protein kinase C gamma type, Gene: PRKCG
Protein: Protein kinase C eta type, Gene: PRKCH
Protein: Protein kinase C iota type, Gene: PRKCI
Protein: Protein kinase C theta type, Gene: PRKCQ
Protein: Protein kinase C zeta type, Gene: PRKCZ
Protein: Serine/threonine-protein kinase D1, Gene: PRKD1
Gene: PRKD2
Protein: Serine/threonine-protein kinase D3, Gene: PRKD3
Protein: Cytochrome P450, Gene: CYP1A1
Protein: Cytochrome P450 2C19, Gene: CYP2C19
Protein: Cytochrome P450 2C9, Gene: CYP2C9
Protein: Cytochrome P450 2E1, Gene: CYP2E1
Gene: CYP3A4
Protein: Equilibrative nucleoside transporter 1, Gene: SLC29A1
Protein: Insulin-like growth factor-binding protein 5, Gene: IGFBP5
Protein: Cytochrome P450 1A2, Gene: CYP1A2
Protein: Plasminogen activator inhibitor 1 RNA-binding protein, Gene: SERBP1
Toxicity
- oral LD50 [mouse] mg/kg
- > 7920.0
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
Anti Inflammation
Anti Cancer
Anti Atherogenic
Anti Diabetic
Anti Convulsant
Neuroprotective
Cardioprotective
Antibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
No dataSuppression of aging mechanisms
Anti Oxidant
Relation to biomarkers of Aging
Data not available
Model organism
ModelCaenorhabditis elegans
SrainN2
Sex—
Age of treatment—
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- 24.4
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0,5%
More info about experiment
Opposite effectNo