Dimethyl Sulfoxide

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CAS: 67-68-5

Name:

Dimethyl Sulfoxide

Other names:

DMSO; Methyl sulfoxide; Dimethyl sulphoxide; Methylsulfinylmethane; Demasorb, Dimexide; Domoso; Demsodrox; Dromisol

A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during cryopreservation. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation. [PubChem]

Interactions

Description

UniProt ID

Protein: UDP-glucuronosyltransferase 1-1, Gene: UGT1A1
Protein: UDP-glucuronosyltransferase 1-10, Gene: UGT1A10
Protein: Occludin, Gene: OCLN
Protein: Protein kinase C alpha type, Gene: PRKCA
Protein: Protein kinase C beta type, Gene: PRKCB
Protein: Protein kinase C delta type, Gene: PRKCD
Protein: Protein kinase C epsilon type, Gene: PRKCE
Protein: Protein kinase C gamma type, Gene: PRKCG
Protein: Protein kinase C eta type, Gene: PRKCH
Protein: Protein kinase C iota type, Gene: PRKCI
Protein: Protein kinase C theta type, Gene: PRKCQ
Protein: Protein kinase C zeta type, Gene: PRKCZ
Protein: Serine/threonine-protein kinase D1, Gene: PRKD1
Gene: PRKD2
Protein: Serine/threonine-protein kinase D3, Gene: PRKD3
Protein: Cytochrome P450, Gene: CYP1A1
Protein: Cytochrome P450 2C19, Gene: CYP2C19
Protein: Cytochrome P450 2C9, Gene: CYP2C9
Protein: Cytochrome P450 2E1, Gene: CYP2E1
Gene: CYP3A4
Protein: Equilibrative nucleoside transporter 1, Gene: SLC29A1
Protein: Insulin-like growth factor-binding protein 5, Gene: IGFBP5
Protein: Cytochrome P450 1A2, Gene: CYP1A2
Protein: Plasminogen activator inhibitor 1 RNA-binding protein, Gene: SERBP1

Toxicity

oral LD50 [mouse] mg/kg
> 7920.0
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Inflammation
Anti Cancer
Anti Atherogenic
Anti Diabetic
Anti Convulsant
Neuroprotective
Cardioprotective
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

No data

Suppression of aging mechanisms

Anti Oxidant

Relation to biomarkers of Aging

Data not available

Relation to aging associated genes

PRKCAPRKCD

Experimental conditions

Not available

Life Extension

Mean LS (%)
24.4
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

0,5%

More info about experiment

20828537
Opposite effectNo