Didanosine

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CAS: 69655-05-6

Name:

Didanosine

Other names:

DIDEOXYINOSINE; Videx; 2',3'-Dideoxyinosine; Videx EC; ddIno; Didanosinum; Didanosina; Hypoxanthine ddN

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite. [PubChem]

Interactions

Description

UniProt ID

Protein: Purine nucleoside phosphorylase, Gene: PNP

Toxicity

oral LD50 [mouse] mg/kg
> 0.0
oral LD50 [rat] mg/kg
> 0.0
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

No data
Antibacterial

No

Antifungal

No

Antiviral

S1702

Longevity mechanisms activation

No data

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Data not available

Relation to aging associated genes

No data available

Experimental conditions

Not available

Life Extension

Mean LS (%)
5.0
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

10 mkM

More info about experiment

7518199
Opposite effectNo