Deprenyl
CAS: 14611-51-9
Name:
Deprenyl
Other names:
Deprenyl; Cognitiv; Niar; Selgin; Selegos; Eldepryl; Jumex; Tumex
A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson’s disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual, 1994, p385) The compound without isomeric designation is Deprenyl. [PubChem]
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Model organism
ModelRat
SrainFischer-344
SexMale
Age of treatment18-24 month
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- 15.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0.5 mg/kg
More info about experiment
Opposite effectNo