D-Glucosamine
CAS: 3416-24-8
Name:
D-Glucosamine
Other names:
chitosamine; 2-Amino-2-deoxy-D-glucose; STK801823; (3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol
Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies. It is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Since glucosamine is a precursor for glycosaminoglycans, and glycosaminoglycans are a major component of joint cartilage, supplemental glucosamine may help to rebuild cartilage and treat arthritis.
Interactions
No targets available
Toxicity
- oral LD50 [mouse] mg/kg
- > 15000.0
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Antibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
No dataSuppression of aging mechanisms
No dataRelation to aging associated genes
No data available
Model organism
ModelCaenorhabditis elegans
SrainN2
Sex—
Age of treatment—
Experimental conditions
Agar nematode growth medium + E. coli OP50Life Extension
- Mean LS (%)
- 8.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- 8.0
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
100 μM
More info about experiment
Opposite effectNo
Model organism
ModelMice
SrainC57BL/6NRj
Sex—
Age of treatment100 weeks
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- —
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
10 g/kg in the diet
More info about experiment
Opposite effectNo
Model organism
ModelHuman
Srain—
Sex—
Age of treatment—
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- —
- Median LS (%)
- —
- Mortality rate derease (%)
- 18.0
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
More info about experiment
Opposite effectNo