Cyproterone Acetate

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CAS: 427-51-0

Name:

Cyproterone Acetate

Other names:

Androcur; Cyproteron acetate; Cyproteron-R acetate; Cyproterone 17-O-acetate; Cyproteroneacetate; SH 714; SH-714

An anti-androgen that, in the form of its acetate (cyproterone acetate), also has progestational properties. It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females. [Pubchem]

Interactions

Description

UniProt ID

Protein: Nuclear receptor subfamily 1 group I member 2, Gene: NR1I2
Protein: Amphiregulin, Gene: AREGAREGB
Protein: Steroid 17-alpha-hydroxylase/17,20 lyase, Gene: CYP17A1
Protein: Estrogen receptor, Gene: ESR1
Protein: Estrogen receptor beta, Gene: ESR2
Protein: Glucocorticoid receptor, Gene: NR3C1
Protein: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2, Gene: HSD3B2
Protein: Free fatty acid receptor 4, Gene: FFAR4

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
> 0.0
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

No data
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

No data

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Hair loss in women

18044109

Relation to aging associated genes

No data available

Experimental conditions

S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50

Life Extension

Mean LS (%)
23.0
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

0,33%

More info about experiment

24134630
Opposite effectNo