Cyproterone Acetate
CAS: 427-51-0
Name:
Cyproterone Acetate
Other names:
Androcur; Cyproteron acetate; Cyproteron-R acetate; Cyproterone 17-O-acetate; Cyproteroneacetate; SH 714; SH-714
An anti-androgen that, in the form of its acetate (cyproterone acetate), also has progestational properties. It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females. [Pubchem]
Interactions
Description
UniProt ID
Protein: Nuclear receptor subfamily 1 group I member 2, Gene: NR1I2
Protein: Amphiregulin, Gene: AREGAREGB
Protein: Steroid 17-alpha-hydroxylase/17,20 lyase, Gene: CYP17A1
Protein: Estrogen receptor, Gene: ESR1
Protein: Estrogen receptor beta, Gene: ESR2
Protein: Glucocorticoid receptor, Gene: NR3C1
Protein: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2, Gene: HSD3B2
Protein: Free fatty acid receptor 4, Gene: FFAR4
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- > 0.0
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
No dataAntibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
No dataSuppression of aging mechanisms
No dataRelation to aging associated genes
No data available
Model organism
ModelCaenorhabditis elegans
SrainN2
Sex—
Age of treatment—
Experimental conditions
S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50Life Extension
- Mean LS (%)
- 23.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0,33%
More info about experiment
Opposite effectNo