CAS: 458-37-7



Other names:

Diferuloylmethane; Natural yellow 3; Turmeric yellow; Turmeric; Kacha haldi; Gelbwurz; Curcuma; Haldar; Souchet

Curcumin (Synthetic), a phenolic pigment originally isolated from Curcuma longa (tumeric) has reported antioxident, anticancer and anti-inflammatory actvities as noted in multiple in vitro studies. A study investigating the effects of curcumin on reported inflammatory mediators in inflammatory bowel disease on colonic myofibroblasts obtained ex vivoreported that a dose-dependent suppression of matrix metalloproteinase-3 (MMP-3) occured. Additional studies report that Curcumin is able to suppress NF-κB, COX-1, COX-2 and TNF-α. Noted in research studies to upregulate PPARγ, p53 and Nrf2. Curcumin (Synthetic) is an inhibitor of 5-LO, Cox-2, CREB Binding Protein, GST, IKK, JNK, NF kappa B, NOS2, NQO1 and p300. Curcumin has been shown to modify histones. In one study, exposure of MCF7 cells to curcumin resulted in increased global levels of acetylated H3K18 and H4K16.



UniProt ID

Protein: Aryl hydrocarbon receptor, Gene: AHR
Protein: Cystic fibrosis transmembrane conductance regulator, Gene: CFTR
Protein: Vitamin D3 receptor, Gene: VDR
Protein: Mitogen-activated protein kinase 11, Gene: MAPK11
Protein: Mitogen-activated protein kinase 12, Gene: MAPK12
Protein: Mitogen-activated protein kinase 13, Gene: MAPK13
Protein: Mitogen-activated protein kinase 14, Gene: MAPK14
Protein: Arachidonate 5-lipoxygenase, Gene: ALOX5
Protein: Apoptosis regulator Bcl-2, Gene: BCL2
Gene: Car15
Protein: Carbonic anhydrase 1, Gene: CA1
Protein: Carbonic anhydrase 2, Gene: CA2
Protein: Carbonic anhydrase 3, Gene: CA3
Protein: Carbonic anhydrase 4, Gene: CA4
Protein: Carbonic anhydrase 9, Gene: CA9
Protein: Carbonic anhydrase 5A, mitochondrial, Gene: CA5A
Protein: Carbonic anhydrase 5B, mitochondrial, Gene: CA5B
Protein: Carbonic anhydrase 6, Gene: CA6
Protein: Carbonic anhydrase 7, Gene: CA7
Protein: Carbonic anhydrase 12, Gene: CA12
Protein: Carbonic anhydrase 13, Gene: CA13
Protein: Carbonic anhydrase 14, Gene: CA14
Protein: Aminopeptidase N, Gene: ANPEP
Protein: DNA polymerase lambda, Gene: POLL
Protein: Receptor tyrosine-protein kinase erbB-2, Gene: ERBB2
Protein: Lactoylglutathione lyase, Gene: GLO1
Protein: Amine oxidase [flavin-containing] A, Gene: MAOA
Protein: 72 kDa type IV collagenase, Gene: MMP2
Protein: Arylamine N-acetyltransferase 2, Gene: NAT2
Gene: NQO1
Protein: EP300-interacting inhibitor of differentiation 2, Gene: EID2
Protein: Serine/threonine-protein kinase PAK 1, Gene: PAK1
Protein: Protein kinase C alpha type, Gene: PRKCA
Protein: Protein kinase C beta type, Gene: PRKCB
Protein: Protein kinase C delta type, Gene: PRKCD
Protein: Protein kinase C epsilon type, Gene: PRKCE
Protein: Protein kinase C gamma type, Gene: PRKCG
Protein: Protein kinase C eta type, Gene: PRKCH
Protein: Protein kinase C iota type, Gene: PRKCI
Protein: Protein kinase C theta type, Gene: PRKCQ
Protein: Protein kinase C zeta type, Gene: PRKCZ
Protein: Serine/threonine-protein kinase D1, Gene: PRKD1
Gene: PRKD2
Protein: Serine/threonine-protein kinase D3, Gene: PRKD3
Protein: Sulfotransferase 1A1, Gene: SULT1A1
Protein: Sulfotransferase 1A3, Gene: SULT1A3
Protein: Sulfotransferase 1A4, Gene: SULT1A4
Protein: Multidrug resistance-associated protein 1, Gene: ABCC1
Protein: Canalicular multispecific organic anion transporter 1, Gene: ABCC2
Protein: ATP-binding cassette sub-family G member 2, Gene: ABCG2
Protein: RAC-alpha serine/threonine-protein kinase, Gene: AKT1
Protein: Nitric oxide synthase, inducible, Gene: NOS2


oral LD50 [mouse] mg/kg
> 0.0
oral LD50 [rat] mg/kg
oral LD50 [rabbit] mg/kg

Effects on organism

Anti Inflammation
Anti Cancer
Anti Atherogenic
Anti Diabetic
Anti Depressant






Longevity mechanisms activation

Stress Resistance

Suppression of aging mechanisms

Induce Autophagy
Anti Oxidant

Relation to biomarkers of Aging

Data not available

Relation to aging associated genes

No data available

Experimental conditions

USP agar nematode growth medium + E. coli OP50

Life Extension

Mean LS (%)
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

100 mkM

More info about experiment

Opposite effect22451473

Experimental conditions

Not available

Life Extension

Mean LS (%)
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

250 mkM

More info about experiment

Opposite effectNo