Clofibrate
CAS: 637-07-0
Name:
Clofibrate
Other names:
Atromid; Arterioflexin; Angiokapsul; Atheropront; Clofibratum; Antilipide; Atheromide; Clofibrato; Lipofacton
A fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p986)
Interactions
Description
UniProt ID
Protein: Glycerol-3-phosphate dehydrogenase, mitochondrial, Gene: GPD2
Protein: Peroxisome proliferator-activated receptor alpha, Gene: PPARA
Protein: Constitutive coactivator of peroxisome proliferator-activated receptor gamma, Gene: FAM120B
Protein: Peroxisomal acyl-coenzyme A oxidase 1, Gene: ACOX1
Protein: Mitochondrial carnitine/acylcarnitine carrier protein, Gene: SLC25A20
Protein: D-amino-acid oxidase, Gene: DAO
Protein: Lipoprotein lipase, Gene: LPL
Gene: MAP2K1
Protein: Dual specificity mitogen-activated protein kinase kinase 2, Gene: MAP2K2
Protein: Nicotinate-nucleotide pyrophosphorylase [carboxylating], Gene: QPRT
Protein: Uricase, Gene: uox
Protein: D-beta-hydroxybutyrate dehydrogenase, mitochondrial, Gene: BDH1
Protein: Carboxylic ester hydrolase, Gene: CES2
Protein: Cytochrome P450 2C9, Gene: CYP2C9
Protein: 5'-AMP-activated protein kinase catalytic subunit alpha-2, Gene: PRKAA2
Protein: 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase, Gene: ACMSD
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- > 940.0
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
Anti Inflammation
Anti Cancer
Anti Atherogenic
Cardioprotective
Antibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
No dataSuppression of aging mechanisms
No dataRelation to aging associated genes
PPARAModel organism
ModelCaenorhabditis elegans
SrainN2
Sex—
Age of treatment—
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- 16.2
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
10 mkM
More info about experiment
Opposite effectNo