Cinnarizine
CAS: 298-57-7
Name:
Cinnarizine
Other names:
Dimitronal; Stutgin; Dimitron; Folcodal; Midronal; Mitronal; Stutgeron; Glanil; Labyrin
Cinnarizine is an anti-histaminic drug which is mainly used for the control of vomiting due to motion sickness.It acts by interfering with the signal transmission between vestibular apparatus of the inner ear and the vomiting centre of the hypothalamus. The disparity of signal processing between inner ear motion receptors and the visual senses is abolished, so that the confusion of brain whether the individual is moving or standing is reduced. Vomiting in motion sickness is actually a physiological compensatory mechanism of the brain to keep the individual from moving so that it can adjust to the signal perception.
Interactions
Description
UniProt ID
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- > 0.0
- oral LD50 [rabbit] mg/kg
- Unavailable
No
No
No
Longevity mechanisms activation
Suppression of aging mechanisms
No dataRelation to biomarkers of Aging
Data not available
Relation to aging associated genes
No data available
Model organism
Experimental conditions
S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50Life Extension
- Mean LS (%)
- 15.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0,33%