Cinnarizine

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CAS: 298-57-7

Name:

Cinnarizine

Other names:

Dimitronal; Stutgin; Dimitron; Folcodal; Midronal; Mitronal; Stutgeron; Glanil; Labyrin

Cinnarizine is an anti-histaminic drug which is mainly used for the control of vomiting due to motion sickness.It acts by interfering with the signal transmission between vestibular apparatus of the inner ear and the vomiting centre of the hypothalamus. The disparity of signal processing between inner ear motion receptors and the visual senses is abolished, so that the confusion of brain whether the individual is moving or standing is reduced. Vomiting in motion sickness is actually a physiological compensatory mechanism of the brain to keep the individual from moving so that it can adjust to the signal perception.

Interactions

Description

UniProt ID

Protein: Estrogen receptor, Gene: ESR1
Protein: Estrogen receptor beta, Gene: ESR2
Protein: Voltage-dependent L-type calcium channel subunit alpha-1D, Gene: CACNA1D
Protein: Voltage-dependent L-type calcium channel subunit alpha-1S, Gene: CACNA1S
Gene: CACNA2D1
Protein: Voltage-dependent L-type calcium channel subunit beta-1, Gene: CACNB1
Protein: Voltage-dependent calcium channel gamma-1 subunit, Gene: CACNG1
Protein: Muscarinic acetylcholine receptor, Gene: CHRM1
Protein: Muscarinic acetylcholine receptor, Gene: CHRM2
Protein: Muscarinic acetylcholine receptor M3, Gene: CHRM3
Protein: Muscarinic acetylcholine receptor M4, Gene: CHRM4
Protein: Muscarinic acetylcholine receptor M5, Gene: CHRM5
Protein: D(2) dopamine receptor, Gene: DRD2
Protein: ATP-dependent RNA helicase DHX8, Gene: DHX8
Protein: 5-hydroxytryptamine receptor 2A, Gene: HTR2A
Protein: 5-hydroxytryptamine receptor 2B, Gene: HTR2B
Protein: 5-hydroxytryptamine receptor 2C, Gene: HTR2C
Protein: Voltage-dependent L-type calcium channel subunit alpha-1C, Gene: CACNA1C
Protein: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Gene: CACNA1A
Protein: 5-hydroxytryptamine receptor 1A, Gene: HTR1A
Protein: 5-hydroxytryptamine receptor 1B, Gene: HTR1B
Protein: 5-hydroxytryptamine receptor 1D, Gene: HTR1D
Protein: 5-hydroxytryptamine receptor 1E, Gene: HTR1E
Protein: 5-hydroxytryptamine receptor 1F, Gene: HTR1F
Protein: 5-hydroxytryptamine receptor 2A, Gene: HTR2A
Protein: 5-hydroxytryptamine receptor 2B, Gene: HTR2B
Protein: 5-hydroxytryptamine receptor 2C, Gene: HTR2C
Protein: 5-hydroxytryptamine receptor 3A, Gene: HTR3A
Protein: 5-hydroxytryptamine receptor 3B, Gene: HTR3B
Protein: 5-hydroxytryptamine receptor 3C, Gene: HTR3C
Protein: 5-hydroxytryptamine receptor 4, Gene: HTR4
Protein: 5-hydroxytryptamine receptor 5A, Gene: HTR5A
Gene: HTR5BP
Protein: 5-hydroxytryptamine receptor 6, Gene: HTR6
Protein: 5-hydroxytryptamine receptor 7, Gene: HTR7
Gene: ITPR1
Protein: Inositol 1,4,5-trisphosphate receptor type 2, Gene: ITPR2
Gene: ITPR3

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
> 0.0
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Inflammation
Anti Convulsant
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

Stress Resistance

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Data not available

Relation to aging associated genes

No data available

Experimental conditions

S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50

Life Extension

Mean LS (%)
15.0
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

0,33%

More info about experiment

24134630
Opposite effectNo