Celecoxib

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CAS: 169590-42-5

Name:

Celecoxib

Other names:

Celebrex; Celebra; 169590-42-5; Celocoxib; Onsenal; Celecox; Celecoxi; Xilebao; SC 58635

Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis. It is marketed by Pfizer under the brand name Celebrex. In some countries, it is branded Celebra.

Interactions

Description

UniProt ID

Protein: Vascular endothelial growth factor A, Gene: VEGFA
Protein: Sodium channel protein type 10 subunit alpha, Gene: SCN10A
Protein: Arachidonate 5-lipoxygenase, Gene: ALOX5
Protein: Carbonic anhydrase 1, Gene: CA1
Protein: Carbonic anhydrase 2, Gene: CA2
Protein: Carbonic anhydrase 4, Gene: CA4
Protein: Carbonic anhydrase 9, Gene: CA9
Protein: Prostaglandin G/H synthase 1, Gene: PTGS1
Protein: Prostaglandin G/H synthase 2, Gene: PTGS2
Protein: Cytochrome P450 1A2, Gene: CYP1A2
Protein: Cytochrome P450 2C8, Gene: CYP2C8
Protein: Cytochrome P450 2D6, Gene: CYP2D6
Protein: 3-phosphoinositide-dependent protein kinase 1, Gene: PDPK1
Protein: Sulfotransferase, Gene: SULT2A1
Protein: Aldehyde oxidase, Gene: AOX1
Protein: Inhibitor of nuclear factor kappa-B kinase subunit alpha, Gene: CHUK
Protein: Mitogen-activated protein kinase 10, Gene: MAPK10
Protein: Mitogen-activated protein kinase 8, Gene: MAPK8
Protein: Mitogen-activated protein kinase 9, Gene: MAPK9
Gene: RELA

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Inflammation
Anti Cancer
Anti Atherogenic
Anti Depressant
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

Stress Resistance

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Management of the Arthritis

22084715

Relation to aging associated genes

No data available

Experimental conditions

Agar nematode growth medium + E. coli OP50

Life Extension

Mean LS (%)
20.0
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

2-10 mkM

More info about experiment

21348927
Opposite effectNo