Celecoxib
CAS: 169590-42-5
Name:
Celecoxib
Other names:
Celebrex; Celebra; 169590-42-5; Celocoxib; Onsenal; Celecox; Celecoxi; Xilebao; SC 58635
Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis. It is marketed by Pfizer under the brand name Celebrex. In some countries, it is branded Celebra.
Interactions
Description
UniProt ID
Protein: Vascular endothelial growth factor A, Gene: VEGFA
Protein: Sodium channel protein type 10 subunit alpha, Gene: SCN10A
Protein: Arachidonate 5-lipoxygenase, Gene: ALOX5
Protein: Carbonic anhydrase 1, Gene: CA1
Protein: Carbonic anhydrase 2, Gene: CA2
Protein: Carbonic anhydrase 4, Gene: CA4
Protein: Carbonic anhydrase 9, Gene: CA9
Protein: Prostaglandin G/H synthase 1, Gene: PTGS1
Protein: Prostaglandin G/H synthase 2, Gene: PTGS2
Protein: Cytochrome P450 1A2, Gene: CYP1A2
Protein: Cytochrome P450 2C8, Gene: CYP2C8
Protein: Cytochrome P450 2D6, Gene: CYP2D6
Protein: 3-phosphoinositide-dependent protein kinase 1, Gene: PDPK1
Protein: Sulfotransferase, Gene: SULT2A1
Protein: Aldehyde oxidase, Gene: AOX1
Protein: Inhibitor of nuclear factor kappa-B kinase subunit alpha, Gene: CHUK
Protein: Mitogen-activated protein kinase 10, Gene: MAPK10
Protein: Mitogen-activated protein kinase 8, Gene: MAPK8
Protein: Mitogen-activated protein kinase 9, Gene: MAPK9
Gene: RELA
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
Anti Inflammation
Anti Cancer
Anti Atherogenic
Anti Depressant
Antibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
Stress Resistance
Suppression of aging mechanisms
No dataRelation to aging associated genes
No data available
Model organism
ModelCaenorhabditis elegans
SrainN2
Sex—
Age of treatment—
Experimental conditions
Agar nematode growth medium + E. coli OP50Life Extension
- Mean LS (%)
- 20.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
2-10 mkM
More info about experiment
Opposite effectNo