Caffeic Acid

Imageshandler

CAS: 331-39-5

Name:

Caffeic Acid

Other names:

3,4-Dihydroxycinnamic acid; trans-Caffeate; 3-(3,4-dihydroxyphenyl)acrylic acid; Cinnamic acid

Caffeic Acid is an endogenous phenolic phytochemical compound that exists in plants and many foods. A major metabolite product upon hydrolization of chlorogenic acid caffeic acid inhibits a number of lipoxygenases such as 5-LO (5-lipoxygenase), in a non-competitive manner, and 12-LO (12-lipoxygenase) inhibiting leukotriene synthesis resulting in further inhibition of immunoregulation. Caffeic Acid has also been shown to inhibit arachidonic acid metabolism in platelets at high doses. It has been observed to stimulate prostaglandin synthesis at high doses. Caffeic Acid is an inhibitor of GST, ODC, Tyk and Xanthine Oxidase.

Interactions

Description

UniProt ID

Protein: Alpha-1A adrenergic receptor, Gene: ADRA1A
Protein: 5'-AMP-activated protein kinase catalytic subunit alpha-2, Gene: PRKAA2
Protein: Aryl hydrocarbon receptor, Gene: AHR
Protein: Alcohol dehydrogenase [NADP(+)], Gene: AKR1A1
Protein: Arachidonate 5-lipoxygenase, Gene: ALOX5
Protein: C-type lectin domain family 14 member A, Gene: CLEC14A
Protein: Chymotrypsin-like elastase family member 1, Gene: CELA1
Protein: Chymotrypsin-like elastase family member 3A, Gene: CELA3A
Protein: Chymotrypsin-like elastase family member 3B, Gene: CELA3B
Protein: Tyrosine-protein kinase Fyn, Gene: FYN
Protein: Beta-hexosaminidase subunit beta, Gene: HEXB
Protein: Neutrophil elastase, Gene: ELANE
Protein: Pancreatic triacylglycerol lipase, Gene: PNLIP
Protein: Amine oxidase [flavin-containing] A, Gene: MAOA
Protein: Amine oxidase [flavin-containing] B, Gene: MAOB
Protein: Arylamine N-acetyltransferase 1, Gene: NAT1
Protein: Tyrosyl-DNA phosphodiesterase 2, Gene: TDP2
Protein: Xanthine dehydrogenase/oxidase, Gene: XDH
Protein: Myeloperoxidase, Gene: MPO
Protein: Sulfotransferase 1A3, Gene: SULT1A3
Protein: Sulfotransferase 1A4, Gene: SULT1A4

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Inflammation
Anti Cancer
Anti Amiloid
Anti Obesity
Neuroprotective
Cardioprotective
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

Stress Resistance

Suppression of aging mechanisms

Anti Age
Anti Oxidant

Relation to biomarkers of Aging

Protective effect of chlorogenic acid against ischemia-reperfusion injury

20933071 21116690

Relation to aging associated genes

TERC

Experimental conditions

Agar nematode growth medium + E. coli OP50

Life Extension

Mean LS (%)
11.0
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

300 mkM

More info about experiment

21503726
Opposite effectNo