Caffeic Acid
CAS: 331-39-5
Name:
Caffeic Acid
Other names:
3,4-Dihydroxycinnamic acid; trans-Caffeate; 3-(3,4-dihydroxyphenyl)acrylic acid; Cinnamic acid
Caffeic Acid is an endogenous phenolic phytochemical compound that exists in plants and many foods. A major metabolite product upon hydrolization of chlorogenic acid caffeic acid inhibits a number of lipoxygenases such as 5-LO (5-lipoxygenase), in a non-competitive manner, and 12-LO (12-lipoxygenase) inhibiting leukotriene synthesis resulting in further inhibition of immunoregulation. Caffeic Acid has also been shown to inhibit arachidonic acid metabolism in platelets at high doses. It has been observed to stimulate prostaglandin synthesis at high doses. Caffeic Acid is an inhibitor of GST, ODC, Tyk and Xanthine Oxidase.
Interactions
Description
UniProt ID
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
No
No
No
Longevity mechanisms activation
Relation to biomarkers of Aging
Protective effect of chlorogenic acid against ischemia-reperfusion injury
Relation to aging associated genes
TERCModel organism
Experimental conditions
Agar nematode growth medium + E. coli OP50Life Extension
- Mean LS (%)
- 11.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
300 mkM