Beta-Estradiol

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CAS: 50-28-2

Name:

Beta-Estradiol

Other names:

beta-Estradiol; 17beta-Estradiol; Estrace; Dihydrofolliculin; Oestradiol; progynon; Aerodiol; Aquadiol; Diogynets

Generally refers to the 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. In humans, it is produced primarily by the cyclic ovaries and the placenta. It is also produced by the adipose tissue of men and postmenopausal women. The 17-alpha-isomer of estradiol binds weakly to estrogen receptors (receptors, estrogen) and exhibits little estrogenic activity in estrogen-responsive tissues. Various isomers can be synthesized.

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DrugBank

ChEMBL

ChEBI

PubChem

Drug Status

Approved

Clinical trials

33 Studies

Interactions

Description

UniProt ID

Protein: Estrogen receptor beta, Gene: ESR2
Q92731
Protein: G-protein coupled estrogen receptor 1, Gene: GPER1
Q99527
Protein: Estrogen receptor, Gene: ESR1
P03372
Protein: Estrogen receptor beta, Gene: ESR2
Q92731
Protein: Nuclear receptor subfamily 1 group I member 2, Gene: NR1I2
O75469
Protein: Calcium-activated potassium channel subunit beta-1, Gene: KCNMB1
Q16558
Protein: ATP-binding cassette sub-family G member 2, Gene: ABCG2
Q9UNQ0
Protein: Aldo-keto reductase family 1 member C4, Gene: AKR1C4
P17516
Protein: Amphiregulin, Gene: AREGAREGB
P15514
Protein: Cytochrome P450 1A2, Gene: CYP1A2
P05177
Gene: CYP1B1
Q53TK1
Protein: Cytochrome P450 2C8, Gene: CYP2C8
P10632
Protein: Estradiol 17-beta-dehydrogenase 1, Gene: HSD17B1
P14061
Protein: Free fatty acid receptor 4, Gene: FFAR4
Q5NUL3
Protein: 3-oxo-5-alpha-steroid 4-dehydrogenase 2, Gene: SRD5A2
P31213
Protein: Corticosteroid-binding globulin, Gene: SERPINA6
P08185
Protein: 3-oxo-5-alpha-steroid 4-dehydrogenase 1, Gene: SRD5A1
P18405
Protein: Ubiquitin-associated and SH3 domain-containing protein B, Gene: UBASH3B
Q8TF42
Protein: Aldehyde oxidase, Gene: AOX1
Q06278
Protein: Solute carrier family 2, facilitated glucose transporter member 1, Gene: SLC2A1
P11166
Protein: 5-hydroxytryptamine receptor 3A, Gene: HTR3A
P46098
Protein: Sodium-dependent serotonin transporter, Gene: SLC6A4
P31645
Protein: Solute carrier family 22 member 1, Gene: SLC22A1
O15245
Protein: Solute carrier family 22 member 3, Gene: SLC22A3
O75751

Related pathways

No information yet

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Inflammation
16427650
Anti Cancer
24934239
Anti Atherogenic
23395521
Anti Diabetic
21521748
Neuroprotective
11095506
Cardioprotective
21700911
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

No data

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Protects human skin fibroblasts and keratinocytes against oxidative damage

22988828

Relation to aging associated genes

ESR1

Model organism

ModelCaenorhabiditis elegans
SrainN2
Sex—
Age of treatment—

Experimental conditions

S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50

Life Extension

Mean LS (%)
7.0
Median LS (%)
—
Mortality rate derease (%)
—
Max LS (%)
—
Cell CLS
—
Cell RLS
—

Concentration wth maximum effect

0,33%

More info about experiment

24134630
Opposite effectNo