Amperozide Hydrochloride

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CAS: 86725-37-3

Name:

Amperozide Hydrochloride

Other names:

Amperozide; Amperozide HCl; NCGC00093556-01; DSSTox_CID_25750; DSSTox_RID_81094; DSSTox_GSID_45750; UNII-8V2171U69N

Amperozide is an atypical antipsychotic of the diphenylbutylpiperazine class which acts as an antagonist at the 5-HT receptor. It does not block dopamine receptors as with most antipsychotic drugs, but does inhibit dopamine release, and alters the firing pattern of dopaminergic neurons. It was investigated for the treatment of schizophrenia in humans, but never adopted clinically, its main use is instead in veterinary medicine, primarily in intensively farmed pigs, for decreasing aggression and stress and thereby increasing feeding and productivity [Wiki].

Interactions

Description

UniProt ID

Protein: Muscarinic acetylcholine receptor, Gene: CHRM1
Protein: Alpha-1A adrenergic receptor, Gene: ADRA1A
Protein: Alpha-1B adrenergic receptor, Gene: ADRA1B
Protein: Alpha-1D adrenergic receptor, Gene: ADRA1D
Protein: Alpha-2B adrenergic receptor, Gene: ADRA2B
Protein: D(2) dopamine receptor, Gene: DRD2
Gene: DRD3
Protein: D(4) dopamine receptor, Gene: DRD4
Protein: D(1B) dopamine receptor, Gene: DRD5
Protein: ATP-dependent RNA helicase DHX8, Gene: DHX8
Protein: 5-hydroxytryptamine receptor 2A, Gene: HTR2A
Protein: 5-hydroxytryptamine receptor 2C, Gene: HTR2C

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Depressant
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

Stress Resistance
+

Suppression of aging mechanisms

No data

Relation to biomarkers of Aging

Data not available

Relation to aging associated genes

No data available

Experimental conditions

S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50

Life Extension

Mean LS (%)
38.0
Median LS (%)
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

0,33%

More info about experiment

24134630
Opposite effectNo