Amperozide Hydrochloride
CAS: 86725-37-3
Name:
Amperozide Hydrochloride
Other names:
Amperozide; Amperozide HCl; NCGC00093556-01; DSSTox_CID_25750; DSSTox_RID_81094; DSSTox_GSID_45750; UNII-8V2171U69N
Amperozide is an atypical antipsychotic of the diphenylbutylpiperazine class which acts as an antagonist at the 5-HT receptor. It does not block dopamine receptors as with most antipsychotic drugs, but does inhibit dopamine release, and alters the firing pattern of dopaminergic neurons. It was investigated for the treatment of schizophrenia in humans, but never adopted clinically, its main use is instead in veterinary medicine, primarily in intensively farmed pigs, for decreasing aggression and stress and thereby increasing feeding and productivity [Wiki].
Interactions
Description
UniProt ID
Protein: Muscarinic acetylcholine receptor, Gene: CHRM1
Protein: Alpha-1A adrenergic receptor, Gene: ADRA1A
Protein: Alpha-1B adrenergic receptor, Gene: ADRA1B
Protein: Alpha-1D adrenergic receptor, Gene: ADRA1D
Protein: Alpha-2B adrenergic receptor, Gene: ADRA2B
Protein: D(2) dopamine receptor, Gene: DRD2
Gene: DRD3
Protein: D(4) dopamine receptor, Gene: DRD4
Protein: D(1B) dopamine receptor, Gene: DRD5
Protein: ATP-dependent RNA helicase DHX8, Gene: DHX8
Protein: 5-hydroxytryptamine receptor 2A, Gene: HTR2A
Protein: 5-hydroxytryptamine receptor 2C, Gene: HTR2C
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
Anti Depressant
Antibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
Stress Resistance
+
Suppression of aging mechanisms
No dataRelation to biomarkers of Aging
Data not available
Relation to aging associated genes
No data available
Model organism
ModelCaenorhabiditis elegans
SrainN2
Sex—
Age of treatment—
Experimental conditions
S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50Life Extension
- Mean LS (%)
- 38.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0,33%
More info about experiment
Opposite effectNo