7-Cyclopentyl-5-(4-Phenoxy)Phenyl-7H-Pyrrolo[2,3-D]Pyrimidin-4-Ylamine
CAS: 213743-31-8
Name:
7-Cyclopentyl-5-(4-Phenoxy)Phenyl-7H-Pyrrolo[2,3-D]Pyrimidin-4-Ylamine
Other names:
Lck Inhibitor; SureCN378454; AC1O7G1S; 7-Cyclopentyl-5-(4-phenoxy)phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine; 7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine; 4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[3,2-d]pyrimidin-7-yl-cyclopentane; 4-Amino-5-(4-Phenoxyphenyl)-7h-Pyrrolo[2,3-D]pyrimidin-7-Yl-Cyclopentane; 3gen; B43; KIN001-051
Lck Inhibitor is a cell-permeable pyrrolopyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of Lck. Also shown to potently block T-cell receptor-stimulated IL-2 production in vitro [Santa Cruz Biotechnology].
Interactions
Description
UniProt ID
Protein: Proto-oncogene tyrosine-protein kinase Src, Gene: SRC
Protein: Cyclin-dependent kinase 1, Gene: CDK1
Protein: C-type lectin domain family 14 member A, Gene: CLEC14A
Protein: Tyrosine-protein kinase Lck, Gene: LCK
Protein: Protein kinase C alpha type, Gene: PRKCA
Protein: Protein kinase C delta type, Gene: PRKCD
Protein: Protein kinase C epsilon type, Gene: PRKCE
Protein: Protein kinase C eta type, Gene: PRKCH
Protein: Protein kinase C gamma type, Gene: PRKCG
Protein: Protein kinase C iota type, Gene: PRKCI
Protein: Protein kinase C theta type, Gene: PRKCQ
Protein: Protein kinase C zeta type, Gene: PRKCZ
Protein: Angiopoietin-1 receptor, Gene: TEK
Protein: Vascular endothelial growth factor receptor 2, Gene: KDR
Protein: Tyrosine-protein kinase ZAP-70, Gene: ZAP70
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Model organism
ModelCaenorhabiditis elegans
SrainN2
Sex—
Age of treatment—
Experimental conditions
S-complete media in wells of 96 well + E. coli OP50plates containing E. coli OP50Life Extension
- Mean LS (%)
- 11.0
- Median LS (%)
- —
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
0,33%
More info about experiment
Opposite effectNo