4-Phenylbutyrate

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CAS: 1716-12-7

Name:

4-Phenylbutyrate

Other names:

PBA; Phenylbutyrate

Sodium phenylbutyrate is a salt of an aromatic fatty acid. The compound is used to treat urea cycle disorders, because its metabolites offer an alternative pathway to the urea cycle to allow excretion of excess nitrogen. Sodium phenylbutyrate is also a histone deacetylase inhibitor and chemical chaperone, leading respectively to research into its use as an anti-cancer agent and in protein misfolding diseases such as cystic fibrosis.

Interactions

No targets available

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
Unavailable

Effects on organism

Anti Inflammation
Anti Cancer
Anti Amiloid
Anti Obesity
Neuroprotective
Cardioprotective
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

Stress Resistance

Suppression of aging mechanisms

Anti Genotoxic

Relation to biomarkers of Aging

Data not available

Relation to aging associated genes

No data available

Experimental conditions

Not available

Life Extension

Mean LS (%)
36.0
Median LS (%)
40.0
Mortality rate derease (%)
Max LS (%)
41.0
Cell CLS
Cell RLS

Concentration wth maximum effect

5 mM

More info about experiment

11792861
Opposite effectNo