4-Phenylbutyrate
CAS: 1716-12-7
Name:
4-Phenylbutyrate
Other names:
PBA; Phenylbutyrate
Sodium phenylbutyrate is a salt of an aromatic fatty acid. The compound is used to treat urea cycle disorders, because its metabolites offer an alternative pathway to the urea cycle to allow excretion of excess nitrogen. Sodium phenylbutyrate is also a histone deacetylase inhibitor and chemical chaperone, leading respectively to research into its use as an anti-cancer agent and in protein misfolding diseases such as cystic fibrosis.
Interactions
No targets available
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- Unavailable
Effects on organism
Anti Inflammation
Anti Cancer
Anti Obesity
Neuroprotective
Cardioprotective
Antibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
Stress Resistance
Suppression of aging mechanisms
Anti Genotoxic
Relation to biomarkers of Aging
Data not available
Relation to aging associated genes
No data available
Model organism
ModelDrosophila melanogaster
SrainW 1118
Sex—
Age of treatment—
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- 36.0
- Median LS (%)
- 40.0
- Mortality rate derease (%)
- —
- Max LS (%)
- 41.0
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
5 mM
More info about experiment
Opposite effectNo