Warning! Toxic compound!
2,4-Dinitrophenol
CAS: 51-28-5
Name:
2,4-Dinitrophenol
Other names:
Aldifen; Solfo Black B; Tertrosulphur PBR; alpha-Dinitrophenol, Phenol, 2,4-dinitro-, Solfo Black G, Nitro kleenup
2,4-Dinitrophenol (2,4-DNP) is an inhibitor of ATP production in cells containing mitochondria. 2,4-DNP uncouples oxidative phosphorylation by carrying protons across the mitochondrial membrane, which leads to a rapid consumption of energy without generation of ATP. 2,4-DNP has been used commercially to make dyes, organic chemicals, photographic developing agents, explosives, herbicides and wood preservatives. In biochemistry research, 2,4-DNP is often used to explore membrane transport processes.
Toxicity
- oral LD50 [mouse] mg/kg
- Unavailable
- oral LD50 [rat] mg/kg
- Unavailable
- oral LD50 [rabbit] mg/kg
- > 30.0
Antibacterial
No
Antifungal
No
Antiviral
No
Longevity mechanisms activation
No dataSuppression of aging mechanisms
Anti Oxidant
Relation to biomarkers of Aging
Data not available
Relation to aging associated genes
No data available
Model organism
ModelMice
SrainSwiss Webster outbred albino mice
SexFemale
Age of treatment18 weeks
Experimental conditions
Not availableLife Extension
- Mean LS (%)
- 7.0
- Median LS (%)
- 7.0
- Mortality rate derease (%)
- —
- Max LS (%)
- —
- Cell CLS
- —
- Cell RLS
- —
Concentration wth maximum effect
30-105 mkg/kg/day
More info about experiment
Opposite effectNo