Warning! Toxic compound!

2,4-Dinitrophenol

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CAS: 51-28-5

Name:

2,4-Dinitrophenol

Other names:

Aldifen; Solfo Black B; Tertrosulphur PBR; alpha-Dinitrophenol, Phenol, 2,4-dinitro-, Solfo Black G, Nitro kleenup

2,4-Dinitrophenol (2,4-DNP) is an inhibitor of ATP production in cells containing mitochondria. 2,4-DNP uncouples oxidative phosphorylation by carrying protons across the mitochondrial membrane, which leads to a rapid consumption of energy without generation of ATP. 2,4-DNP has been used commercially to make dyes, organic chemicals, photographic developing agents, explosives, herbicides and wood preservatives. In biochemistry research, 2,4-DNP is often used to explore membrane transport processes.

Interactions

Description

UniProt ID

Gene: onr

Toxicity

oral LD50 [mouse] mg/kg
Unavailable
oral LD50 [rat] mg/kg
Unavailable
oral LD50 [rabbit] mg/kg
> 30.0

Effects on organism

Anti Amiloid
Anti Obesity
Neuroprotective
Antibacterial

No

Antifungal

No

Antiviral

No

Longevity mechanisms activation

No data

Suppression of aging mechanisms

Anti Oxidant

Relation to biomarkers of Aging

Data not available

Relation to aging associated genes

No data available

Experimental conditions

Not available

Life Extension

Mean LS (%)
7.0
Median LS (%)
7.0
Mortality rate derease (%)
Max LS (%)
Cell CLS
Cell RLS

Concentration wth maximum effect

30-105 mkg/kg/day

More info about experiment

18505478
Opposite effectNo